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6. Shannen Doherty and Jason Priestly

Sometimes true love outlasts the show, and other times the show goes on after the love fades. In case of Shannen Doherty and Jason Priestly, the latter was the case. Playing twin brother and sister Brandon and Brenda in Beverly Hills 90210, the duo hooked up during the first season, and broke off soon after. They would continue to star in their sibling roles on the show for years, but it seems the love never returned.


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